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1 Separate ascending and descending pathways of serotonin (5-hy-droxytryptamine, 5-HT) nerves in the rat central nervous system have been selectively lesioned by Idealized intracerebral administration of 5,7-dihydroxytryptamine (5,7-DHT) after pretreatment with desipramine (DMI). 2 Bilateral injections of 5,7-DHT into the medial forebrain bundle or the cervical spinal cord caused extensive losses of 5-HT and tryptophan hydroxylase in the anterior hypothalamus and thoracic spinal cord, respectively, without affecting noradrenaline (NA) levels. 3 The hypothalamic lesions caused only a slight, transient reduction of systolic blood pressure in normotensive rats. 4 A more pronounced and sustained hypotension occurred in normotensive rats but not in hypertensive rats after the spinal lesions.
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Howe et al. (1982) studied this question.
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