October 1, 1987Journal of Cardiovascular Pharmacology

Diverse Vascular Responses to Serotonin in the Conscious Rabbit

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Population

conscious rabbits

Design

Preclinical

Authors

CWChristine E. WrightThe University of Melbourne JAJames A. AngusVascular / Pulmonary Vascular

Discussion

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Implication

Serotonergic agents may risk renal ischemia via 5-HT2 spasm; leaves open human translation of differential vascular responses.

Structured PICO

Population

conscious rabbits

Intervention

serotonin (5-HT) infusion, 3-60 micrograms/kg/min i.v., after autonomic ganglion blockade (mecamylamine), with or without antagonists (prazosin, ketanserin, methysergide, methiothepin) or 5-Carboxamidotryptamine (5-CT)

Outcome

Vascular conductance in the mesenteric, hindquarter, and renal bedssurrogate

In conscious rabbits, serotonin induces renal artery spasm mediated by 5-HT2 receptors, while causing vasodilation in mesenteric and hindquarter beds via 5-HT1-like receptors.

Cite This Study

Wright et al. (1987) studied this question.

synapsesocial.com/papers/6a904329f009383eee841817 https://doi.org/10.1097/00005344-198710000-00006

View Full Paper

Ask AI

Bookmark

Diverse Vascular Responses to Serotonin in the Conscious Rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Diverse Vascular Responses to Serotonin in the Conscious Rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider