Why the study?
Does serotonin enhance sympathetic vasoconstrictor responses in rat tail arteries via serotonin-2 receptors?
Population
Rat isolated perfused/superfused proximal tail artery segments
Comparison
Serotonin (6 nmol/l) and ketanserin (3 nmol/l) vs Baseline/control responses to electrical…
Design
Preclinical
Authors
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Serotonin-2 blockade may blunt enhanced sympathetic vasoconstriction in rat arteries; leaves open relevance to human vascular tone.
Does serotonin enhance sympathetic vasoconstrictor responses in rat tail arteries via serotonin-2 receptors?
Serotonin enhances sympathetic vasoconstriction in rat tail arteries via postjunctional serotonin-2 receptors, an effect blocked by ketanserin.
Medgett et al. (1984) studied this question.
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