NT-proBNP level before primary PCI and risk of poor myocardial reperfusion: Insight from the On-TIME II trial
Why the study?
Because NT-proBNP levels may reflect extensive ischemia and microvascular damage, the authors investigated the potential association between baseline NT-proBNP and ST-resolution after primary PCI.
Is baseline NT-proBNP level associated with poor myocardial reperfusion (STR <70%) after primary PCI in STEMI patients?
Population
918 STEMI patients with baseline NT-proBNP before angiography
Comparison
Baseline NT-proBNP levels
Design
Post-hoc analysis of a randomized trial
Follow-up
1 hour after pPCI
Authors
Discussion
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Member takes
Implication
May refine reperfusion risk stratification in STEMI; hypothesis-generating and should not yet change practice.
Structured PICO
Is baseline NT-proBNP level associated with poor myocardial reperfusion (STR <70%) after primary PCI in STEMI patients?
P
Population
918 STEMI patients with measured NT-proBNP before angiography undergoing primary percutaneous coronary intervention (pPCI)
I
Intervention
Baseline NT-proBNP level
O
Outcome
ST-resolution (STR) <70% one hour after pPCI (poor myocardial reperfusion)surrogate
Higher baseline NT-proBNP levels in STEMI patients are independently associated with poor myocardial reperfusion after primary PCI, suggesting its utility for early risk stratification.
Cite This Study
Fabris et al. (2020) studied this question.