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Experimental study demonstrates sequencing of 130 and 200 base-pair DNA fragments via mass spectrometry, indicating potential for routine genetic analysis.
Sequencing of DNA fragments of 130 and 200 bp using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for DNA ladder detection was demonstrated. With further improvement in mass resolution and detection sensitivity, mass spectrometry shows great promise for routine DNA sequencing in the future.
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Taranenko et al. (1998) studied this question.
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