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January 1, 2006Journal of Clinical Laboratory AnalysisOpen Access

Natriuretic peptide Val7Met substitution and risk of coronary artery disease in Greek patients with familial hypercholesterolemia

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Why the study?

Do ANP polymorphisms affect lipid levels and CAD risk in patients with familial hypercholesterolemia?

Population

83 Greek patients with familial hypercholesterolemia (FH)

Comparison

Presence of ANP polymorphisms vs Absence of these polymorphisms

Design

Cross-sectional

Authors

GDGeorge DedoussisGeneral / Preventive / LipidsSMSandy MaumusJSJohn SkoumasNational and Kapodistrian University of Athens

Discussion

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Implication

No immediate implications for CAD risk assessment in familial hypercholesterolemia; leaves open ANP effects on ApoA1/HDL-C for further study.

Structured PICO

Do ANP polymorphisms affect lipid levels and CAD risk in patients with familial hypercholesterolemia?

P
Population
83 Greek patients with familial hypercholesterolemia (FH)
I
Intervention
Presence of ANP polymorphisms (T2238C and G664A/Val7Met)
C
Comparator
Absence of these polymorphisms (e.g., GG homozygotes for G664A)
O
Outcome
Apolipoprotein (Apo) A1 levels and coronary artery disease (CAD) risksurrogate

The ANP G664A polymorphism is associated with lower ApoA1 and HDL-C levels in patients with familial hypercholesterolemia, but does not appear to influence the risk of coronary artery disease.

Cite This Study

Dedoussis et al. (2006) studied this question.

synapsesocial.com/papers/6a7d23752ad457ac68775291https://doi.org/10.1002/jcla.20108

Topics

Coronary artery disease
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Also Consider

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