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February 1, 2000Clinical ChemistryOpen Access

Very Small Apolipoprotein A-I-containing Particles from Human Plasma: Isolation and Quantification by High-Performance Size-Exclusion Chromatography

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Population

30 subjects with HDL-cholesterol (HDL-C) concentrations of 0.4-3.83 mmol/L

Design

Other

Authors

MNM. Nazeem NanjeeUniversity of UtahEBEliot A. BrintonPreventive Cardiology

Discussion

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Implication

Novel HP-SEC isolates small LpA-I particles; extends HDL research tools while leaving clinical implications open.

Structured PICO

P
Population
30 subjects with HDL-cholesterol (HDL-C) concentrations of 0.4-3.83 mmol/L
I
Intervention
High-performance size-exclusion chromatography (HP-SEC) using two gel permeation columns in series
O
Outcome
Isolation and quantification of very small apolipoprotein A-I-containing particles (Sm LpA-I)surrogate

A novel HP-SEC method enables the isolation and quantification of very small apo A-I-containing particles, providing a tool for further studies on HDL metabolism and atherosclerosis protection.

Cite This Study

Nanjee et al. (2000) studied this question.

synapsesocial.com/papers/6a89d3910e1a8f7244fd5febhttps://doi.org/10.1093/clinchem/46.2.207
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge1972 · 32,638 citations
  2. 2Interconversion between apolipoprotein A-I-containing lipoproteins of pre-beta and alpha electrophoretic mobilities.1992 · 126 citations
  3. 3Biochemical Characterization of Pre-β1 High-Density Lipoprotein from Human Ovarian Follicular Fluid: Evidence for the Presence of a Lipid Core,1996 · 71 citations
  4. 4Physiological role and clinical relevance of high-density lipoprotein subclasses1994 · 152 citations
  5. 5Factors affecting the integrity of high density lipoproteins in the ultracentrifuge1982 · 196 citations