Key result
Large and small LpA-I populations had mean diameters of 109 Å and 91 Å, containing 3.0 and 3.7 molecules of APOA1 per particle, respectively, suggesting a ratchet model for HDL structure.
Why the study?
Human HDL containing APOA1 but not APOA2 (LpA-I) is composed of two discretely sized populations whose molecular characteristics and structural determinants required deep characterization.
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Isolation of distinct LpA-I subpopulations enables functional dissection; leaves open any role in cardiovascular risk stratification.
Melchior et al. (2021) studied this question. Apolipoprotein A-I (APOA1) and A-II (APOA2) was evaluated on Particle size and protein cargo distribution of LpA-I. Large and small LpA-I populations had mean diameters of 109 Å and 91 Å, containing 3.0 and 3.7 molecules of APOA1 per particle, respectively, suggesting a ratchet model for HDL structure.
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