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January 1, 2015Pharmacology

Discrepancies in Assessment of Adherence to Antiplatelet Treatment after Myocardial Infarction

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Why the study?

Does self-reported adherence accurately reflect drug availability-based adherence to clopidogrel in patients post-myocardial infarction?

Population

184 patients treated with primary percutaneous coronary intervention for acute myocardial infarction

Comparison

Assessment of clopidogrel adherence using drug… vs Assessment of clopidogrel adherence using…

Design

Cohort

Follow-up

3, 6 and 9 months after discharge

Authors

AKAldona KubicaMKMichał KasprzakKOKarolina Obońska

Discussion

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Member takes

Overview

Self-reported adherence overestimates availability-based measures post-MI; leaves open whether objective monitoring improves outcomes.

Structured PICO

Does self-reported adherence accurately reflect drug availability-based adherence to clopidogrel in patients post-myocardial infarction?

P
Population
184 patients treated with primary percutaneous coronary intervention for acute myocardial infarction (STEMI and NSTEMI)
I
Intervention
Assessment of clopidogrel adherence using drug availability (prescription refill data from the National Health Fund)
C
Comparator
Assessment of clopidogrel adherence using self-reported drug intake
O
Outcome
Discrepancy in adherence rates between drug availability and self-reported methods

Self-reported adherence to clopidogrel significantly overestimates true adherence compared to pharmacy refill data in post-MI patients, highlighting the need for objective adherence measures.

Cite This Study

Kubica et al. (2015) studied this question.

synapsesocial.com/papers/6a7d23cd469c795fc4278fa3https://doi.org/10.1159/000371392
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors associated with clopidogrel use, adherence, and persistence in patients with acute coronary syndromes undergoing percutaneous coronary intervention2011 · 40 citations
  2. 2Diurnal variation in platelet inhibition by clopidogrel2011 · 64 citations
  3. 3Ischaemic and bleeding complications with new, compared to standard, ADP-antagonist regimens in acute coronary syndromes: a meta-analysis of randomized trials2011 · 44 citations
  4. 4Cardiovascular Outcomes after a Change in Prescription Policy for Clopidogrel2008 · 83 citations
  5. 5Influence of genetic polymorphisms on platelet function, response to antiplatelet drugs and clinical outcomes in patients with coronary artery disease2013 · 25 citations