Key result
After one week of electronic adherence monitoring, antiplatelet resistance remained present in 20% of aspirin and 25% of clopidogrel patients, suggesting non-adherence is not the main cause.
Why the study?
Does monitored adherence using POEMS reduce antiplatelet resistance in outpatients on chronic aspirin and/or clopidogrel?
Population
82 outpatients with chronic aspirin (n=69) and/or clopidogrel (n=32) treatment
Comparison
One-week period of measuring patient's adherence… vs Baseline (before adherence monitoring)
Design
Cohort
Follow-up
1 week
Authors
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Non-adherence should not yet be assumed primary in antiplatelet resistance; leaves open diabetes, inflammation, and interactions for targeted study.
Observational (n=82)
Does monitored adherence using POEMS reduce antiplatelet resistance in outpatients on chronic aspirin and/or clopidogrel?
Multidrug adherence monitoring demonstrated that non-adherence is not a major contributor to antiplatelet resistance in outpatients, highlighting the role of diabetes, inflammation, and drug-drug interactions.
Walter et al. (2013) conducted an observational in Antiplatelet resistance (n=82). Electronic adherence monitoring (POEMS) vs. Baseline (before monitoring) was evaluated on Antiplatelet resistance. After one week of electronic adherence monitoring, antiplatelet resistance remained present in 20% of aspirin and 25% of clopidogrel patients, suggesting non-adherence is not the main cause.
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