Why the study?
The role of natriuretic peptides in the pathogenesis of AF and HF is not entirely understood, prompting investigation into their causal relationships using Mendelian randomization.
Does genetic predisposition to higher natriuretic peptide levels cause incident atrial fibrillation or heart failure?
Does genetic predisposition to higher natriuretic peptide levels cause incident atrial fibrillation or heart failure?
A Mendelian randomization study found no strong causal relationship between genetically determined natriuretic peptide levels and the incidence of atrial fibrillation or heart failure, suggesting therapeutic approaches targeting these peptides work through indirect mechanisms.
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No strong causal link ruled out in community cohorts; leaves open subtler or subgroup-specific effects.
Geelhoed et al. (2020) studied this question.
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