Why the study?
The study was conducted to identify possible statistical hypotheses regarding death and cancer after percutaneous transluminal coronary angioplasty with drug-eluting stents for a subsequent large-sample study.
Exploratory clustering analysis suggests that death cases among patients receiving drug-eluting stents cluster based on available variables, whereas cancer cases do not.
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Exploratory signals on post-DES mortality and cancer generate hypotheses; leaves open whether therapy changes are warranted pending larger studies.
We present an exploratory study of a group of patients (150) who have undergone precutaneous transluminal coronary angioplasty with the use of drug eluting stents.We concentrate on the most often studied rare adverse event, i.e. death, as well as the still unexplored cancer variable.The aim of the study is to identify possible statistical hypotheses for a subsequent, large sample study.The results of this study may lead to a change in the therapy administered after precutaneous coronary interventions which will reduce the mortality rate.To achieve this, we use clustering techniques such as hierarchical cluster analysis, principal components methods and interactive brushing.We show that death cases cluster in the space defined by the available variables, while the cancer cases do not seem to cluster.
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A 2020 study studied this question.
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