Why the study?
Does lidocaine reverse cocaine-induced electrocardiographic changes in isolated guinea pig hearts?
Population
20 isolated, Tyrode-perfused guinea pig hearts
Comparison
Cocaine concentrations ranging from 3-195 microM… vs Cocaine alone
Design
Preclinical
Authors
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Lidocaine may not safely reverse all cocaine ECG effects; leaves open mechanistic questions for human translation.
Does lidocaine reverse cocaine-induced electrocardiographic changes in isolated guinea pig hearts?
Lidocaine reverses cocaine-induced slowed ventricular conduction through competition for binding but appears to increase cocaine-induced prolongation of repolarization in isolated guinea pig hearts.
Grawe et al. (1994) studied this question.