Key result
Sodium bicarbonate significantly reduced cocaine-induced prolongation of PR, AH, and HV intervals, and QRS duration (p < 0.05), whereas sodium chloride had no effect.
Why the study?
Does sodium bicarbonate improve cocaine-induced ECG changes compared to sodium chloride in a canine model of cocaine toxicity?
Population
17 anesthetized dogs receiving three i.v. injections of cocaine (5 mg/kg, separated by 15 min)
Comparison
2 mEq/kg i.v. sodium bicarbonate (1 mEq/ml) vs 2 mEq/kg i.v. sodium chloride (1 mEq/ml)
Design
Preclinical, randomly assigned
Authors
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Bicarbonate may reverse cocaine-induced conduction delays in dogs; leaves open translation to human overdose management.
RCT (n=17)
randomly assigned
Does sodium bicarbonate improve cocaine-induced ECG changes compared to sodium chloride in a canine model of cocaine toxicity?
p-value: p=<0.05
Sodium bicarbonate effectively reverses cocaine-induced slowing of cardiac conduction due to increased arterial pH, whereas sodium chloride has no effect.
Parker et al. (1999) conducted an RCT in Cocaine-induced ECG changes (n=17). Sodium bicarbonate vs. Sodium chloride was evaluated on Reversal of cocaine-induced effects on the electrocardiogram (PR, AH, HV intervals, and QRS duration) (p=<0.05). Sodium bicarbonate significantly reduced cocaine-induced prolongation of PR, AH, and HV intervals, and QRS duration (p < 0.05), whereas sodium chloride had no effect.
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