October 15, 1996Circulation
Relative Role of Alkalosis and Sodium Ions in Reversal of Class I Antiarrhythmic Drug–Induced Sodium Channel Blockade by Sodium Bicarbonate
Why the study?
Does increased sodium and/or bicarbonate concentration reverse the sodium channel-blocking effects of class I antiarrhythmic drugs in canine Purkinje fibers?
Population
Canine Purkinje fibers
Comparison
Altered solutions in the presence of class I… vs Normal Tyrode solution
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May attenuate sodium channel blockade by select class I agents in vitro; leaves open translation to human toxicity management.
Structured PICO
Does increased sodium and/or bicarbonate concentration reverse the sodium channel-blocking effects of class I antiarrhythmic drugs in canine Purkinje fibers?
P
Population
Canine Purkinje fibers
I
Intervention
Altered solutions (increased sodium concentration, increased bicarbonate concentration, or both) in the presence of class I antiarrhythmic drugs (disopyramide 30 μmol/L, mexiletine 80 μmol/L, flecainide 7 μmol/L, imipramine 5 μmol/L)
C
Comparator
Normal Tyrode solution
O
Outcome
Action potential characteristics, specifically phase 0 upstroke (Vmax)surrogate
Increases in sodium bicarbonate concentration reverse the effects of class I antiarrhythmic drugs to varying extents, with drug-specific contributions of the sodium and bicarbonate moieties.
Cite This Study
Bou‐Abboud et al. (1996) studied this question.