Why the study?
Does lidocaine reverse cocaine-induced slowing of ventricular conduction in isolated guinea pig hearts?
Population
26 isolated, Tyrode-perfused guinea pig hearts exposed to cocaine 30 microM
Comparison
Equimolar lidocaine, equimolar quinidine, or… vs Cocaine-induced baseline
Design
Preclinical
Authors
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Does not support clinical use in cocaine toxicity; leaves open translation from guinea pig hearts to humans.
Does lidocaine reverse cocaine-induced slowing of ventricular conduction in isolated guinea pig hearts?
Lidocaine effectively reverses cocaine-induced slowing of ventricular conduction in a preclinical model, suggesting potential as an antidote for cocaine-induced arrhythmias.
Winecoff et al. (1994) studied this question.
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