Population
12- to 16-week-old male mice lacking the gene for endothelial nitric oxide synthase and the corresponding…
Comparison
eNOS gene knockout (eNOS-/-) vs C57Bl/6J control mice
Design
Preclinical
Follow-up
24 hours
Authors
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eNOS-/- mouse data remain preclinical and should not alter hypertension care; leaves open endothelial NO contributions to human BP lability.
eNOS-/- mice exhibit mild hypertension with pronounced increases in blood pressure lability and reactivity, which is markedly affected by locomotor activity.
Vliet et al. (2003) studied this question.
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