August 1, 1992Endocrinology

Regulation of insulin-like growth factor binding protein-3 messenger ribonucleic acid expression by insulin-like growth factor I.

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Population

Cultured bovine and human fibroblasts (normal and SV40-transformed)

Comparison

Insulin-like growth factor I, insulin, IGF-I… vs Untreated cells

Design

Preclinical

Authors

LBLaurie K. BaleMayo Clinic CCCheryl A. ConoverMayo Clinic

Discussion

Member takes

Implication

Species difference in IGF-I control of IGFBP-3 mRNA leaves open optimal fibroblast models; supports bovine cells for transcriptional regulation studies.

Structured PICO

Population

Cultured bovine and human fibroblasts (normal and SV40-transformed)

Intervention

Insulin-like growth factor I (IGF-I), insulin, IGF-I analogs, actinomycin D, and growth hormone (GH)

Comparator

Untreated cells

Outcome

Expression of IGFBP-3 mRNA and secreted IGFBP-3 proteinsurrogate

Expression of mRNA encoding IGFBP-3 is differentially controlled by IGF-I in bovine and human fibroblasts, suggesting different models for studying transcriptional versus posttranscriptional regulation.

Cite This Study

Bale et al. (1992) studied this question.

synapsesocial.com/papers/6a7d2bf8d3686d25b46e4dfe https://doi.org/10.1210/endo.131.2.1379162

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Implication

Species difference in IGF-I control of IGFBP-3 mRNA leaves open optimal fibroblast models; supports bovine cells for transcriptional regulation studies.