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May 20, 2003Arteriosclerosis Thrombosis and Vascular Biology

Contribution of von Willebrand Factor to Thrombus Formation on Neointima of Rabbit Stenotic Iliac Artery Under High Blood-Flow Velocity

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Why the study?

Does a monoclonal antibody against von Willebrand factor reduce thrombus formation and neointimal growth in a rabbit model of stenotic iliac artery injury?

Population

Rabbit repeated balloon-injury model

Design

Preclinical

Follow-up

4 weeks after the second balloon injury

Authors

AYAtsushi YamashitaUniversity of MiyazakiYAYujiro AsadaVascular / Pulmonary VascularHSHiroshi SugimuraKameda Medical Center

Discussion

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Implication

Supports vWF inhibition to limit post-injury thrombosis and restenosis in models; leaves open translation to human interventions.

Structured PICO

Does a monoclonal antibody against von Willebrand factor reduce thrombus formation and neointimal growth in a rabbit model of stenotic iliac artery injury?

P
Population
Rabbit repeated balloon-injury model (iliac arteries 4 weeks after first balloon injury showing 37% luminal stenosis and 2.1 times increased blood velocity)
I
Intervention
Intravenous administration of a monoclonal antibody against von Willebrand factor (AJW200, 1.0 mg/kg body weight)
O
Outcome
Thrombus formation, cell proliferation, and subsequent neointimal growthsurrogate

Inhibition of von Willebrand factor significantly reduces fibrin-rich thrombus formation and neointimal growth in a rabbit model of stenotic arterial injury, suggesting a potential therapeutic target for post-intervention thrombosis.

Cite This Study

Yamashita et al. (2003) studied this question.

synapsesocial.com/papers/6a7d32117786afdcaca00581https://doi.org/10.1161/01.atv.0000077206.35631.b2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Redistribution of von Willebrand Factor in Porcine Carotid Arteries After Balloon Angioplasty1997 · 30 citations
  2. 2Pharmacokinetics and Pharmacodynamics of AJW200, a Humanized Monoclonal Antibody to von Willebrand Factor, in Monkeys2002 · 87 citations
  3. 3Heightened Tissue Factor Associated With Tissue Factor Pathway Inhibitor and Prognosis in Patients With Unstable Angina1999 · 195 citations
  4. 4Tissue Factor Modulates the Thrombogenicity of Human Atherosclerotic Plaques1997 · 607 citations
  5. 5Adenovirus-Mediated Local Expression of Human Tissue Factor Pathway Inhibitor Eliminates Shear Stress–Induced Recurrent Thrombosis in the Injured Carotid Artery of the Rabbit1999 · 69 citations