Why the study?
Do calcium-entry blockers improve systemic and brachial arterial compliance in patients with essential hypertension?
Do calcium-entry blockers improve systemic and brachial arterial compliance in patients with essential hypertension?
Calcium-entry blockers improve arterial compliance in essential hypertension, which may have important consequences for cardiovascular structure and function.
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May support arterial compliance as therapeutic target in hypertension; leaves open randomized outcome trials.
Calcium-entry blockers dilate small arteries as well as large arteries, particularly in the brachial and the carotid circulations. This dilating effect is associated with an increase in systemic and brachial arterial compliance, which is poorly related to the level in blood pressure. Calcium-entry blockers are able to reverse the reduced arterial compliance observed in patients with essential hypertension, with important consequences to the structure and function of the heart and large vessels.
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Safar et al. (1989) studied this question.
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