Why the study?
Does the SPTLC3 rs364585 SNP A allele affect serum lipid profiles in Han and Jing Chinese populations?
Population
1,607 unrelated individuals from two Chinese ethnic groups (824 Han and 783 Jing)
Comparison
Presence of SPTLC3 rs364585 SNP A allele vs Absence of SPTLC3 rs364585 SNP A allele
Design
Cross-sectional
Authors
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Does not support genotype-guided lipid management; hypothesis-generating for ethnic-specific dyslipidemia genetics in Chinese populations.
Does the SPTLC3 rs364585 SNP A allele affect serum lipid profiles in Han and Jing Chinese populations?
The SPTLC3 rs364585 SNP A allele is associated with an atherogenic lipid profile (higher LDL-C and TC, lower HDL-C) in Han and Jing Chinese populations, with potential ethnic and sex specificity.
Zhang et al. (2017) studied this question.
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