What question did this study set out to answer?

To quantify and compare the relative risk reductions in major cardiovascular events achieved with different blood pressure-lowering regimens in younger (<65 years) and older (≥65 years) adults.

May 14, 2008BMJOpen Access

Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials

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Why the study?

Does blood pressure lowering therapy reduce major cardiovascular events differently in younger (<65 years) versus older (≥65 years) adults?

Population

190,606 participants from 31 randomized trials, analyzed by age groups (<65 vs ≥65 years)

Comparison

Different regimens and drug classes to lower… vs Compared across age groups (<65 vs ≥65 years)

Design

Meta-analysis

Discussion

Member takes

Implication

Supports BP lowering for CV prevention across adult ages; reinforces uniform relative efficacy independent of age.

Key Points

To quantify and compare the relative risk reductions in major cardiovascular events achieved with different blood pressure-lowering regimens in younger (<65 years) and older (≥65 years) adults.
Conducted meta-analyses and meta-regression analyses across 31 randomized clinical trials comprising 190,606 participants.
Evaluated differences in treatment efficacy between age categories (<65 vs. ≥65 years) and tested for treatment-by-age interactions by treating age as a continuous variable for the primary outcome of total major cardiovascular events.
Identified no significant difference in treatment efficacy between age groups for major cardiovascular events in meta-regression (<65 vs. ≥65 years; P=0.38) or among individual drug classes (all P ≥ 0.24).
Demonstrated no significant interaction between continuous age and treatment effect on major cardiovascular events across the included trials (all P > 0.09).

Structured PICO

Does blood pressure lowering therapy reduce major cardiovascular events differently in younger (<65 years) versus older (≥65 years) adults?

Population

190,606 participants from 31 randomized trials, analyzed by age groups (<65 vs ≥65 years)

Intervention

Different regimens and drug classes to lower blood pressure

Comparator

Compared across age groups (<65 vs ≥65 years)

Outcome

Total major cardiovascular eventscomposite

Blood pressure lowering provides similar relative protection against major cardiovascular events in both younger and older adults, regardless of the drug class used.

Cite This Study

A 2008 study studied this question.

synapsesocial.com/papers/6a7d38cb1e40f44868965933 https://doi.org/10.1136/bmj.39548.738368.be

Topics

Hypertension management

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Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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