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May 1, 2000Arteriosclerosis Thrombosis and Vascular Biology

Well-Defined Regions of Apolipoprotein B-100 Undergo Conformational Change During Its Intravascular Metabolism

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Population

VLDL, IDL, and LDL subfractions isolated from 6 normolipidemic subjects

Comparison

Analysis using a panel of 29 well-characterized… vs Comparison across VLDL, IDL, and LDL subfractions

Design

Preclinical

Authors

XWXingyu WangJilin UniversityRPRichard J. PeaseUniversity of LeedsJBJesse BertinatoHealth Canada

Discussion

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Implication

No immediate clinical implications; extends apoB structural insights in animal lipoprotein metabolism but remains hypothesis-generating.

Structured PICO

P
Population
VLDL, IDL, and LDL subfractions isolated from 6 normolipidemic subjects
I
Intervention
Analysis using a panel of 29 well-characterized anti-apoB monoclonal antibodies in a solid-phase radioimmunoassay
C
Comparator
Comparison across VLDL, IDL, and LDL subfractions (large, medium, and small)
O
Outcome
Differential expression of individual apoB epitopessurrogate

Conformational changes in apolipoprotein B-100 occur at precise points during the metabolic conversion of VLDL to LDL, limited to well-defined regions of the apoB structure.

Cite This Study

Wang et al. (2000) studied this question.

synapsesocial.com/papers/6a7d3df8d85f1805a31cd40chttps://doi.org/10.1161/01.atv.20.5.1301
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of apolipoprotein B antigenic determinants in human low density lipoprotein subclasses.1985 · 81 citations
  2. 2Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.1991 · 171 citations
  3. 3THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM1955 · 8,814 citations
  4. 4Apoprotein B structure and receptor recognition of triglyceride-rich low density lipoprotein (LDL) is modified in small LDL but not in triglyceride-rich LDL of normal size.1994 · 181 citations
  5. 5Apolipoprotein B-100: conservation of lipid-associating amphipathic secondary structural motifs in nine species of vertebrates1998 · 69 citations