Population
Cardiomyocytes differentiated from the H1 and HES2 human embryonic stem cell lines, and human fetal and…
Comparison
Pharmacological and electrical probing of… vs Human fetal and adult left ventricular…
Design
Preclinical
Authors
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Indicates need for maturation protocols in hESC-CMs; leaves open in vivo functional integration for cardiac regeneration.
Human embryonic stem cell-derived cardiomyocytes possess functional but immature sarcoplasmic reticula for calcium handling, lacking key regulatory proteins present in adult cardiomyocytes.
Liu et al. (2007) studied this question.
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