Key result
Human embryonic stem cell-derived cardiomyocytes depend on transsarcolemmal Ca2+ influx rather than sarcoplasmic reticulum Ca2+ release for contraction, differing from adult myocardium.
Authors
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Hypothesis-generating for hESC-CM myocardial regeneration; leaves open in vivo functional integration and clinical translation.
Dolnikov et al. (2005) studied this question. Human embryonic stem cell-derived cardiomyocytes vs. Adult porcine myocardium was evaluated on Intracellular Ca2+ handling and the role of the sarcoplasmic reticulum in contraction. Human embryonic stem cell-derived cardiomyocytes depend on transsarcolemmal Ca2+ influx rather than sarcoplasmic reticulum Ca2+ release for contraction, differing from adult myocardium.
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