Answers are grounded in this paper and cite their sources.
Demonstrates that methoxamine alters systemic pressures and vascular resistance in left-to-right cardiac shunts, indicating minimal effect on overall shunt magnitude.
In nine patients with atrial septal defect (ASD), five with ventricular septal defect (VSD) and one with persistent ductus arteriosus (PDA) hemodynamic examinations have been performed before and after injection of the vasopressor agent methoxamine. On an average 8 mg methoxamine was injected into the pulmonary artery. An insignificant increase of the left‐to‐right shunt was observed. Significant changes were decrease of heart rate, increase of systemic systolic pressure, mean pulmonary capillary wedge pressure and arteriovenous O 2 ‐difference. Stroke volume and systemic arteriolar resistance increased, and these changes were significant in ASD, insignificant in VSD. The rise in pulmonary arterial mean pressure and oxygen consumption, reduction in cardiac output and pulmonary arteriolar resistance were insignificant.
No takes yet. Share an insight, caveat, or question.
Abrahamsen et al. (1972) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: