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May 2, 2025Journal of Stroke and Cerebrovascular DiseasesOpen Access

Elevated CMI was significantly associated with increased stroke risk with a pooled RR of 1.66 (95% CI: 1.25 to 2.20, I² = 0%).

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Why the study?

The cardiometabolic index integrates cardiovascular and metabolic risk factors into a single measure, but its link to stroke risk and predictive value required systematic evaluation.

Does an elevated cardio-metabolic index (CMI) increase the risk of stroke?

Population

Over 100,000 participants across 5 studies

Comparison

Elevated CMI vs lower CMI

Design

Systematic review and meta-analysis of observational studies

Authors

PSPrakasini SatapathyMKMahalaqua Nazli KhatibSGSubbulakshmi Ganesan

Discussion

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Overview

CMI associated with higher stroke risk in observational data; hypothesis-generating and requires prospective validation before clinical adoption.

Structured PICO

Does an elevated cardio-metabolic index (CMI) increase the risk of stroke?

P
Population
Over 100,000 participants from 5 observational studies (cohort, cross-sectional, and case-control)
I
Intervention
Elevated cardio-metabolic index (CMI)
C
Comparator
Lower cardio-metabolic index (CMI)
O
Outcome
Risk of strokehard clinical

Elevated cardio-metabolic index is strongly associated with an increased risk of stroke, suggesting its potential utility in routine health screenings for early identification and prevention.

Cite This Study

Satapathy et al. (2025) studied this question.

synapsesocial.com/papers/6a7d40bf1e40f44868965b95https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108337
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations of cardiometabolic index with stroke outcomes in European and American cohorts2026
  2. 2Association between cardiometabolic index and stroke risk: insights from the CHARLS cohort study2025
  3. 3Association of cardiometabolic index with prevalence of stroke, all-cause and cardiovascular mortality: a prospective cohort study2026
  4. 4Modified cardiometabolic index and stroke risk: Evidence from the CHARLS cohort2026
  5. 5Rising cardiovascular metabolic indices are associated with hypertension and stroke risk in individuals with abnormal glucose metabolism: A prospective cohort study2026