What is the clinical evidence from this study?

Study design: Cohort. Population: Stroke (n=454293). Intervention: Cardiometabolic index (CMI). Primary outcome: Incident ischemic stroke (HR 1.24, 95% CI 1.21-1.28).

What does this research mean for the field?

Each unit increase in the cardiometabolic index is associated with a 24% higher risk of ischemic stroke and an 11% increased risk of cerebrovascular mortality. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association between the cardiometabolic index and the risk of incident ischemic stroke, hemorrhagic stroke, and cerebrovascular mortality across diverse large-scale cohorts.

September 19, 2026Journal of Stroke and Cerebrovascular DiseasesOpen Access

Each unit increase in cardiometabolic index is linked to ~24% higher ischemic stroke risk.

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Why the study?

Is a higher cardiometabolic index associated with an increased risk of incident stroke and cerebrovascular mortality in European and American cohorts?

Population

454,293 individuals from the UK Biobank (n=413,686) and NHANES (n=40,607) cohorts

Comparison

Higher cardiometabolic index (CMI) vs Lower cardiometabolic index (CMI)

Design

Cohort

Key result

Each unit increase in the cardiometabolic index was associated with a 24% higher risk of ischemic stroke (HR 1.24; 95% CI 1.21-1.28) and an 11% increased risk of cerebrovascular mortality.

Authors

GWGuiqing Wang SWShengping Wang HLHang Li

Discussion

Member takes

Overview

CMI may refine stroke risk assessment in large cohorts; extends prior associations but remains hypothesis-generating without prospective validation.

Key Points

To evaluate the association between the cardiometabolic index and the risk of incident ischemic stroke, hemorrhagic stroke, and cerebrovascular mortality across diverse large-scale cohorts.
Analyzed prospective cohort data from the UK Biobank (n=413,686) and NHANES (n=40,607).
Applied multivariate Cox proportional hazards regression models to evaluate associations between cardiometabolic index and stroke outcomes.
Used restricted cubic splines to characterize potential non-linear dose-response relationships.
Restricted cubic spline analysis showed non-linear relationships between the cardiometabolic index and both ischemic and hemorrhagic stroke.
In fully adjusted models, each unit increase in cardiometabolic index was associated with an increased risk of ischemic stroke (HR = 1.24, 95% CI: 1.21–1.28) and cerebrovascular mortality (HR = 1.11, 95% CI: 1.01–1.21).
Observed associations between the cardiometabolic index and stroke were stronger among females and younger individuals, with genetic susceptibility and metabolic dysfunction jointly amplifying risk.

Study Design

Type

Cohort (n=454,293)

Multicenter

Yes

Structured PICO

Is a higher cardiometabolic index associated with an increased risk of incident stroke and cerebrovascular mortality in European and American cohorts?

Population

454,293 participants from the UK Biobank and NHANES cohorts evaluated for the association between cardiometabolic index and incident stroke and cerebrovascular mortality.

Exposure

Higher cardiometabolic index (CMI)

Comparator

Lower cardiometabolic index (CMI)

Outcome

Incident ischemic/hemorrhagic stroke and cerebrovascular mortalityhard clinical

Main Result

Hazard Ratio: 1.24 (95% CI 1.21–1.28)

The cardiometabolic index is a significant, non-linear predictor of incident ischemic stroke and cerebrovascular mortality in large European and American cohorts.

Limitations

Further validation is needed to assess clinical utility and feasibility of CMI-based screening strategies

Cite This Study

Wang et al. (2026) conducted a cohort in Stroke (n=454,293). Cardiometabolic index (CMI) was evaluated on Incident ischemic stroke (HR 1.24, 95% CI 1.21-1.28). Each unit increase in the cardiometabolic index was associated with a 24% higher risk of ischemic stroke (HR 1.24; 95% CI 1.21-1.28) and an 11% increased risk of cerebrovascular mortality.

synapsesocial.com/papers/6aae47640c69660b71ecc670 https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108748

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September 19, 2026Journal of Stroke and Cerebrovascular DiseasesOpen Access

Each unit increase in cardiometabolic index is linked to ~24% higher ischemic stroke risk.

View Full Paper

Ask AI

Bookmark

Why the study?

Is a higher cardiometabolic index associated with an increased risk of incident stroke and cerebrovascular mortality in European and American cohorts?

Population

454,293 individuals from the UK Biobank (n=413,686) and NHANES (n=40,607) cohorts

Comparison

Higher cardiometabolic index (CMI) vs Lower cardiometabolic index (CMI)

Design

Cohort

Key result

Each unit increase in the cardiometabolic index was associated with a 24% higher risk of ischemic stroke (HR 1.24; 95% CI 1.21-1.28) and an 11% increased risk of cerebrovascular mortality.

Authors

GWGuiqing Wang SWShengping Wang HLHang Li

Discussion

Member takes

Overview

CMI may refine stroke risk assessment in large cohorts; extends prior associations but remains hypothesis-generating without prospective validation.

Key Points

To evaluate the association between the cardiometabolic index and the risk of incident ischemic stroke, hemorrhagic stroke, and cerebrovascular mortality across diverse large-scale cohorts.
Analyzed prospective cohort data from the UK Biobank (n=413,686) and NHANES (n=40,607).
Applied multivariate Cox proportional hazards regression models to evaluate associations between cardiometabolic index and stroke outcomes.
Used restricted cubic splines to characterize potential non-linear dose-response relationships.
Restricted cubic spline analysis showed non-linear relationships between the cardiometabolic index and both ischemic and hemorrhagic stroke.
In fully adjusted models, each unit increase in cardiometabolic index was associated with an increased risk of ischemic stroke (HR = 1.24, 95% CI: 1.21–1.28) and cerebrovascular mortality (HR = 1.11, 95% CI: 1.01–1.21).
Observed associations between the cardiometabolic index and stroke were stronger among females and younger individuals, with genetic susceptibility and metabolic dysfunction jointly amplifying risk.

Study Design

Type

Cohort (n=454,293)

Multicenter

Yes

Structured PICO

Is a higher cardiometabolic index associated with an increased risk of incident stroke and cerebrovascular mortality in European and American cohorts?

Population

454,293 participants from the UK Biobank and NHANES cohorts evaluated for the association between cardiometabolic index and incident stroke and cerebrovascular mortality.

Exposure

Higher cardiometabolic index (CMI)

Comparator

Lower cardiometabolic index (CMI)

Outcome

Incident ischemic/hemorrhagic stroke and cerebrovascular mortalityhard clinical

Main Result

Hazard Ratio: 1.24 (95% CI 1.21–1.28)

The cardiometabolic index is a significant, non-linear predictor of incident ischemic stroke and cerebrovascular mortality in large European and American cohorts.

Limitations

Further validation is needed to assess clinical utility and feasibility of CMI-based screening strategies

Cite This Study

synapsesocial.com/papers/6aae47640c69660b71ecc670 https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108748

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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