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July 1, 2002AJP Heart and Circulatory Physiology

Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats

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Population

37 rats (23 rats with myocardial infarction after left coronary artery ligation and 14 sham-operated rats)

Comparison

Doppler echocardiography vs Invasive hemodynamic measurements

Design

Preclinical

Follow-up

3 months after surgery

Authors

FPFabrice PrunierRGRoger GaertnerLLLiliane Louedec

Discussion

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Overview

Supports non-invasive LVEDP estimation in rat MI models; leaves open translation to clinical use.

Structured PICO

P
Population
37 rats (23 rats with myocardial infarction after left coronary artery ligation and 14 sham-operated rats)
I
Intervention
Doppler echocardiography (pulse wave spectral Doppler at the mitral valve tip and spectral Doppler tissue imaging)
C
Comparator
Invasive hemodynamic measurements
O
Outcome
Correlation between Doppler echocardiographic parameters (E, E/A, DT, Ea, E/Ea) and invasively measured left ventricular end-diastolic pressure (LVEDP)surrogate

Doppler echocardiography, specifically the E/Ea ratio, can reliably estimate left ventricular end-diastolic pressure in rat models of myocardial infarction, allowing for non-invasive serial assessment.

Cite This Study

Prunier et al. (2002) studied this question.

synapsesocial.com/papers/6a7d4147fac401f278425bcfhttps://doi.org/10.1152/ajpheart.01050.2001
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Also Consider

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