Why the study?
Does intramyocardial injection of hydrogels prevent post-infarct ventricular remodeling in patients with myocardial infarction?
Does intramyocardial injection of hydrogels prevent post-infarct ventricular remodeling in patients with myocardial infarction?
This review summarizes the principles, mechanisms, and prospects of injectable hydrogel therapies to prevent post-infarct ventricular remodeling.
Injectable hydrogels remain investigational for post-MI remodeling; leaves open the need for randomized human trials before clinical consideration.
Survivors from myocardial infarction(MI) eventually develop heart failure due to the post-infarct ventricular remodeling which could not be suppressed by existing treatments. Currently, coronary heart disease has become the major cause of heart failure instead of rheumatic heart disease in China. For this reason, seeking effective treatment to prevent post-infarct ventricular remodeling is urgent. Intramyocardial injection of hydrogels as a new strategy for MI treatment has made great progress recently. This review discusses the principle, present status,mechanisms and prospects of injectable hydrogel therapies for MI.
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Wen et al. (2017) studied this question.
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