Population
Cultured primary embryonic chick cardiomyocytes, skeletal myotubes, and non-muscle cells
Design
Preclinical
Authors
Loading...
Animal data on titin z-repeats should not change practice; leaves open their therapeutic potential in cardiomyopathy models.
The z-repeats of cardiac titin are primarily responsible for targeting titin fragments to the Z-band in muscle cells and dense bodies in non-muscle cells, and their over-expression disrupts these structures.
Ayoob et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: