Synthesis of Tetrazole Regioisomers of Biphenyl as ACE Inhibitors

Novel angiotensin converting enzyme (ACE) inhibitors were designed based on the structure of commercially available sartans and synthesized by N-alkylation of 5-substituted-1Htetrazole with 4'-(bromomethyl)-biphenyl-2-carbonitrile gave 1,5-and 2,5-regioisomers of tetrazole. The nitrile group appended to biphenyl nucleus was converted into tetrazole and later the tetrazole was ring transformed into 1,3,4-oxadiazole. The synthesized compounds were screened for the ACE inhibition and some of the compounds exhibited significant results.