Determination of Dissociation Constants of Some Novel Tetrahydropyrimidine Derivatives in Mixed Organic-Water System by Simple pH Measurement

Some tetrahydropyrimidine derivatives have been synthesized and their structures have been confirmed by IR, 1 H NMR, 13 C NMR and mass spectral data. The dissociation constants of these derivatives of tetrahydropyrimidine have been measured by Calvin Bjerrum pH titration method in DMF-water (60: 40 v/v) system at 303.15 K. It is observed that dissociation constant depends on substituent groups present in the compounds.