Synthesis of Some Coumarin and Diazepine Derivatives and Evaluation of Their Antibacterial Activities

In preparations of some coumarin derivatives, salicylaldehyde was reacted with ethyl acetoacetate in a catalytic amount of piperidine to produce 3-acetylcoumarin 3 through a reaction like Pechmann condensation.The product was then condensed with aromatic aldehydes to produce coumarinyl derivatives as chalcones 5a-b.These, in turn, were reacted with o-phenylene diamine to obtain the corresponding diazepines 7a-b.On the other hand, the synthesized products were examined for their antibacterial activity.Structures of the synthesized products were confirmed with the help of their melting points, TLC analysis and spectral data.