Why the study?
Does single-dose oral telmisartan inhibit the angiotensin II pressor response in healthy volunteers challenged with i.v. angiotensin II?
Population
48 healthy volunteers challenged with hypertension-inducing doses of i.v. angiotensin II
Comparison
Single-dose oral administration of telmisartan… vs Single-dose oral placebo (n=12)
Design
RCT, double-blind
Follow-up
48 h
Authors
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Supports once-daily telmisartan dosing via 48-hour effect; confirms dose-dependent AT1 blockade in angiotensin II challenge models.
Does single-dose oral telmisartan inhibit the angiotensin II pressor response in healthy volunteers challenged with i.v. angiotensin II?
Single-dose oral telmisartan provides rapid, dose-dependent, and prolonged inhibition of angiotensin II-induced blood pressure increases in healthy volunteers.
Stangier et al. (2001) studied this question.
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