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March 18, 2015PLoS GeneticsOpen Access

A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

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Population

7,017 individuals not receiving antihypertensive drug treatment

Design

Meta-analysis

Authors

THTianxiao HuanTETõnu EskoMPMarjolein J. Peters

Discussion

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Overview

Should not yet alter hypertension management; extends transcriptomic insights into blood pressure but requires causal validation.

Structured PICO

P
Population
7,017 individuals not receiving antihypertensive drug treatment (pooled from 6 studies of global gene expression profiles of blood pressure and hypertension in whole blood)
O
Outcome
Differential gene expression in relation to blood pressuresurrogate

This meta-analysis identified 34 genes associated with blood pressure regulation, providing novel transcriptomic markers and insights into the molecular mechanisms of hypertension.

Cite This Study

Huan et al. (2015) studied this question.

synapsesocial.com/papers/6a7d51bbc7e6f6a50737d450https://doi.org/10.1371/journal.pgen.1005035
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