February 1, 1996Circulation

1,3 Butadiene, a Vapor Phase Component of Environmental Tobacco Smoke, Accelerates Arteriosclerotic Plaque Development

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Why the study?

Does exposure to 1,3 butadiene or NNK accelerate arteriosclerotic plaque development in cockerels?

Structured PICO

Does exposure to 1,3 butadiene or NNK accelerate arteriosclerotic plaque development in cockerels?

Population

Cockerels (animal model for arteriosclerosis)

Intervention

Inhaled 1,3 butadiene (20 ppm; 16 weeks) or injected 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) (10 mg/kg biweekly, 16 weeks)

Comparator

Filtered air (for butadiene control) or injected dimethylsulfoxide (for NNK control)

Outcome

Plaque incidence, prevalence, location, and sizesurrogate

1,3 butadiene, a vapor phase component of environmental tobacco smoke, significantly accelerates arteriosclerotic plaque development in a cockerel model, suggesting vapor phase components may drive ETS-related cardiovascular risk.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Butadiene may drive ETS plaque effects in animals; leaves open translation to human cardiovascular risk.

Cite This Study

Penn et al. (1996) studied this question.

synapsesocial.com/papers/6a7d57bcda72e8de9c279a9c https://doi.org/10.1161/01.cir.93.3.552

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1,3 Butadiene, a Vapor Phase Component of Environmental Tobacco Smoke, Accelerates Arteriosclerotic Plaque Development

Structured PICO

Discussion

Implication

Cite This Study

1,3 Butadiene, a Vapor Phase Component of Environmental Tobacco Smoke, Accelerates Arteriosclerotic Plaque Development

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider