Why the study?
Does distribution-based analysis improve QTc determination in patients undergoing a thorough QT study?
Does distribution-based analysis improve QTc determination in patients undergoing a thorough QT study?
Distribution-based analysis of the QT interval provides a more statistically powerful method for clinical heart rate correction, potentially reducing the required sample size for thorough QT studies.
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May reduce sample sizes for thorough QT studies; leaves open prospective validation before regulatory adoption.
Holzgrefe et al. (2011) studied this question.
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