January 1, 2015Cellular Physiology and BiochemistryOpen Access

Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Through NF-κB/Brg1 and TGF-ß1 Pathways Attenuates Cardiac Remodeling in Pressure-Overloaded Rat Hearts

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Why the study?

Does PPARγ activation attenuate cardiac remodeling in pressure-overloaded rat hearts?

Population

Rat model of pressure overload-induced cardiac remodeling and cultured neonatal rat cardiomyocytes and…

Design

Preclinical

Authors

HQHanping QiHarbin Medical University YWYe WangHarbin University of Science and Technology QZQianhui ZhangSun Yat-sen University

Discussion

Member takes

Implication

Hypothesis-generating for PPARγ in pressure-overload remodeling; prospective human studies needed before clinical consideration.

Structured PICO

Does PPARγ activation attenuate cardiac remodeling in pressure-overloaded rat hearts?

Population

Rat model of pressure overload-induced cardiac remodeling (abdominal aorta ligation) and cultured neonatal rat cardiomyocytes and cardiac fibroblasts treated with 100 nM angiotensin II

Intervention

Activation of PPARγ

Outcome

Cardiac function, interstitial fibrosis, and expressions of Brg1, TGF-β1, collagen-I, collagen-III, and NF-κBsurrogate

PPARγ activation attenuates pressure overload-induced cardiac remodeling and fibrosis via the NF-κB/Brg1 and TGF-β1 pathways in preclinical models.

Cite This Study

Qi et al. (2015) studied this question.

synapsesocial.com/papers/6a7d61d82c71273e4183ea0a https://doi.org/10.1159/000369747

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Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Through NF-κB/Brg1 and TGF-ß1 Pathways Attenuates Cardiac Remodeling in Pressure-Overloaded Rat Hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Through NF-κB/Brg1 and TGF-ß1 Pathways Attenuates Cardiac Remodeling in Pressure-Overloaded Rat Hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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