Why the study?
Does human Urotensin II administration cause hemodynamic collapse in anesthetized cynomolgus monkeys?
Population
Anesthetized cynomolgus monkeys (n=4)
Design
Preclinical
Follow-up
Acute (immediate post-infusion)
Authors
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May caution UII-targeted therapies in primates; leaves open its role in human cardiovascular pathophysiology.
Does human Urotensin II administration cause hemodynamic collapse in anesthetized cynomolgus monkeys?
Systemic administration of human Urotensin II in nonhuman primates causes severe myocardial depression, pulmonary hypertension, and fatal circulatory collapse, highlighting its profound hemodynamic effects.
Zhu et al. (2004) studied this question.
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