Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2015JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCHOpen Access

Utility of Heart-type Fatty Acid Binding Protein as a New Biochemical Marker for the Early Diagnosis of Acute Coronary Syndrome

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does H-FABP measurement improve the early diagnosis of acute coronary syndrome compared to hs-TnT in patients presenting with chest pain?

Population

88 subjects, including 34 with ischemic chest pain, 29 with non-ischemic chest pain, and 25 normal subjects.

Comparison

Heart-type Fatty Acid Binding Protein measurement vs High-sensitive Troponin T (hs-TnT) measurement

Design

Cross-sectional

Follow-up

0-6 hours

Authors

BGBhakti N GamiBhavnagar University

Discussion

Loading...

Member takes

Implication

May support earlier ACS diagnosis; hypothesis-generating and requires prospective validation before practice change.

Structured PICO

Does H-FABP measurement improve the early diagnosis of acute coronary syndrome compared to hs-TnT in patients presenting with chest pain?

P
Population
88 subjects, including 34 with ischemic chest pain, 29 with non-ischemic chest pain, and 25 normal subjects.
I
Intervention
Heart-type Fatty Acid Binding Protein (H-FABP) measurement
C
Comparator
High-sensitive Troponin T (hs-TnT) measurement
O
Outcome
Diagnostic accuracy (Area Under the Curve, sensitivity, specificity) for myocardial infarction within 0-6 hours of chest pain presentationsurrogate

H-FABP demonstrates higher specificity and comparable sensitivity to hs-TnT, suggesting it may be a useful adjunctive biomarker for the early diagnosis of acute myocardial infarction within 6 hours of symptom onset.

Cite This Study

Bhakti N Gami (2015) studied this question.

synapsesocial.com/papers/6a7d6992ff1a536db837dd18https://doi.org/10.7860/jcdr/2015/11006.5451
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heart-type Fatty Acid Binding Protein as an Adjunct to Cardiac Troponin-I for the Diagnosis of Myocardial Infarction2010 · 14 citations
  2. 2Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction2013 · 81 citations
  3. 3Unbound Free Fatty Acids and Heart-Type Fatty Acid–Binding Protein: Diagnostic Assays and Clinical Applications2005 · 138 citations
  4. 4Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction1997 · 127 citations
  5. 5Office Cardiologists Cooperative Study on Whole Blood Rapid Panel Tests in Patients With Suspicious Acute Myocardial Infarction2004 · 68 citations