Key result
Heart-type fatty acid binding protein (H-FABP) demonstrated significantly higher sensitivity than troponin T (60% vs 19%; P<0.05) for the early diagnosis of acute myocardial infarction.
Why the study?
Does H-FABP measurement improve the early diagnosis of acute myocardial infarction compared to troponin T in emergency room patients with suspected ACS?
Population
419 emergency room patients with suspected acute coronary syndrome (ACS) lasting less than 3 hours
Comparison
Heart-type fatty acid binding protein measurement vs Conventional biomarkers (troponin T)
Design
Cohort
Authors
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May aid early AMI detection in suspected ACS; leaves open routine adoption pending prospective validation.
Observational (n=419)
Yes
Does H-FABP measurement improve the early diagnosis of acute myocardial infarction compared to troponin T in emergency room patients with suspected ACS?
Absolute Event Rate: 60% vs 19%
p-value: p=<0.05
H-FABP demonstrates significantly higher sensitivity than troponin T for the early diagnosis of acute myocardial infarction within the first 3 hours of symptom onset.
Valle et al. (2008) conducted an observational in Suspected acute coronary syndrome (n=419). Heart-type fatty acid binding protein (H-FABP) vs. Troponin T was evaluated on Sensitivity for diagnosing acute myocardial infarction (p=<0.05). Heart-type fatty acid binding protein (H-FABP) demonstrated significantly higher sensitivity than troponin T (60% vs 19%; P<0.05) for the early diagnosis of acute myocardial infarction.
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