August 1, 2002ImmunologyOpen Access

Macrophage phagocytosis of foot‐and‐mouth disease virus may create infectious carriers

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Population

Macrophages interacting with foot-and-mouth disease virus (FMDV) in vitro

Design

Preclinical

Follow-up

up to 48 hours

Authors

RRRachael C. RigdenNational Eye Institute CCCarlos P. CarrascoInstitute of Virology of the Slovak Academy of Sciences ASArtur SummerfieldUniversity of Bern

Discussion

Member takes

Implication

Macrophages may transport infectious FMDV without degradation; leaves open their role in vivo persistence or spread.

Structured PICO

Population

Macrophages interacting with foot-and-mouth disease virus (FMDV) in vitro

Intervention

In vitro interaction with FMDV in the absence of specific antibodies

Outcome

Viral infectivity, antigen presence, and internalization over timesurrogate

Macrophages can internalize foot-and-mouth disease virus without degrading it for at least 10 hours, potentially acting as carriers that transport infectious virus to other sites in the body.

Cite This Study

Rigden et al. (2002) studied this question.

synapsesocial.com/papers/6a7d6c53dbf90a74e583d8da https://doi.org/10.1046/j.1365-2567.2002.01460.x

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Macrophage phagocytosis of foot‐and‐mouth disease virus may create infectious carriers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Macrophage phagocytosis of foot‐and‐mouth disease virus may create infectious carriers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider