Progression of preclinical diastolic dysfunction to the development of symptoms
Population
82 patients with normal systolic function and moderate or severe diastolic dysfunction by Doppler criteria…
Design
Cohort
Follow-up
2 years
Authors
Discussion
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Implication
Low HF progression but substantial symptom burden in preclinical diastolic dysfunction; leaves open targeted prevention strategies in prospective cohorts.
Structured PICO
P
Population
82 patients with normal systolic function (EF ≥50%) and moderate or severe diastolic dysfunction by Doppler criteria, without any clinical diagnosis of HF or HF symptoms (dyspnoea, oedema, fatigue) at the time of echocardiography, and no grade 3 or greater valvular dysfunction (except tricuspid). Mean age 69±10 years, 67% female.
O
Outcome
Time to the development of (1) HF according to the Framingham criteria or (2) any symptoms of dyspnoea, oedema or fatiguecomposite
Patients with preclinical diastolic dysfunction have a low 2-year progression to clinical heart failure but a moderate progression to symptoms and cardiac hospitalizations, with peripheral vascular disease and hypertension independently associated with symptom development.
Cite This Study
de et al. (2010) studied this question.