A subset of normal healthy individuals asymptomatically exhibits a syndrome of defective collagen-induced platelet aggregation and reversible ADP-aggregation.
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Defective platelet aggregation occurs asymptomatically in healthy volunteers; leaves open its prevalence and clinical relevance in larger populations.
Summary Systemic studies on platelet functions of normal healthy individuals were carried out in two independent centres. Both samples of 40 volunteers comprised several individuals (Amsterdam 3 and Utrecht 5 individuals) with a syndrome consisting of an absent collagen-induced platelet aggregation, a reversible ADP-aggregation and frequently a decreased platelet retention in the glass bead column. Occasionally the platelet factor-3 availability was decreased.
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Cate et al. (1971) studied this question.
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