What question did this study set out to answer?

The aim is to develop and evaluate thiazole-based carbamate hybrids for antibacterial and antifungal activities.

Synthesis, antimicrobial evaluation, and computational investigation of novel thiazole-carbamate hybrids as dual antibacterial and antifungal agents

View Full Paper

Ask AI

Bookmark

Randomized trial evaluates antibacterial and antifungal properties of thiazole-carbamate hybrids, indicating potential efficacy.

The aim is to develop and evaluate thiazole-based carbamate hybrids for antibacterial and antifungal activities.
Synthesis of thiazole-carbamate hybrids through reaction of aminothiazole with chloroformates and hydrolysis to carbamate acids.
Evaluation of antibacterial activities against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and antifungal activities against C. albicans using broth dilution technique.
Computational studies including docking analysis and molecular dynamics simulations to assess interaction with DNA gyrase.
Compounds 5d, 6d, 7d, 5e, and 7g exhibited high antibacterial activity with an MIC of 62.5 μg/mL against P. aeruginosa and E. coli.
Compounds 5a, 5g, 6a, 6f, 6g, and 7d showed antifungal activity with MIC values of 250 μg/mL against C. albicans, comparable to griseofulvin.
Docking analysis identified compounds 5a, 5g, and 6f as promising inhibitors of DNA gyrase, with docking scores of −6.6 to −7.6 kcal/mol.

A 2026 study studied this question.

View Full Paper

Ask AI

Bookmark