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August 13, 2026Scientific ReportsOpen Access

Biological maturation may contribute to difference in neutrophil mobilization and IL-8 responses following repeated sprint exercise in athletes: a quasi-experimental study

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Implication

Quasi-experimental study shows that biological maturation influences immune responses to exercise in athletes, suggesting tailored training strategies.

Key Points

  • Investigate the differences in neutrophil and IL-8 responses after repeated sprint exercise based on biological maturation stages.
  • Non-randomized blinded quasi-experimental design with 30 trained athletes including 20 adolescents and 10 adults.
  • Circulating neutrophils and IL-8 levels measured before and during recovery after a standardized repeated sprint exercise protocol.
  • Leukocyte counts assessed by hematology analyzer, neutrophil phenotype evaluated using flow cytometry and microscopy.
  • RSE caused a significant increase in circulating neutrophil counts across all groups (p < 0.05).
  • Adults and circum-PHV athletes displayed greater and more sustained neutrophil responses compared to pre-PHV athletes.
  • IL-8 levels rose acutely, following the neutrophil response patterns (p < 0.001).

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a7d75f62b0e0cff3f63ef93https://doi.org/10.1038/s41598-026-64898-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of repeated sprint exercise on immunological responses in adult and adolescent athletes at different stages of biological maturation: a-quasi-experimental-trial2025 · 5 citations
  2. 2The effect of repeated sprints on immunological modulation and the role of fat-free mass, biological maturation and dietary inflammatory index in male athletes: a quasi-experimental study with insights for training loads control2025 · 1 citations
  3. 3Tissue damage, myocardial injury and recruitment of mature and banded neutrophils after high-intensity endurance exercise2025 · 1 citations
  4. 4Differential Inflammatory Response to Exhaustive Exercise in Trained and Untrained Individuals: Potential Biomarkers of Training Adaptation2026
  5. 5Acute phase response in exercise. III. Neutrophil and IL-1 beta accumulation in skeletal muscle1993 · 419 citations