What question did this study set out to answer?

This study aims to assess the prognostic value of the systemic immune-inflammation index in predicting 28-day mortality in sepsis-associated acute kidney injury.

August 13, 2026European journal of medical researchOpen Access

Development and external validation of a systemic immune-inflammation index-based prognostic model for 28-day mortality in sepsis-associated acute kidney injury

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Authors

QPQingqing Pang BWBo Wang HXHengbo Xia

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Implication

Randomized trial evaluates a prognostic model predicting mortality in sepsis-associated AKI, suggesting clinical utility for risk stratification.

Key Points

This study aims to assess the prognostic value of the systemic immune-inflammation index in predicting 28-day mortality in sepsis-associated acute kidney injury.
Utilized MIMIC-IV database with 1,994 patients and an external validation cohort of 486 patients.
Developed a prognostic model via LASSO regression and multivariable Cox proportional hazards regression.
Assessed model performance using AIC, C-index, time-dependent AUC, and Kaplan–Meier survival analysis.
SII-based model achieved a C-index of 0.667 for predicting 7- to 28-day survival.
The model successfully stratified patients into high- and low-risk groups with significant survival differences (P < 0.05).
Consistent predictive performance was observed in both internal and external validation cohorts.

Cite This Study

Pang et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76bd2b0e0cff3f6405c1 https://doi.org/10.1186/s40001-026-05013-4

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Implication

Randomized trial evaluates a prognostic model predicting mortality in sepsis-associated AKI, suggesting clinical utility for risk stratification.

Development and external validation of a systemic immune-inflammation index-based prognostic model for 28-day mortality in sepsis-associated acute kidney injury

Discussion

Member takes

Implication

Key Points

Cite This Study

Development and external validation of a systemic immune-inflammation index-based prognostic model for 28-day mortality in sepsis-associated acute kidney injury

Discussion

Member takes

Implication

Key Points

Cite This Study

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