What question did this study set out to answer?

The aim is to assess which of the SII, NLR, and SIRI best predicts adverse outcomes in patients with sepsis-associated acute kidney injury.

Comparison of SII, NLR, and SIRI for severity stratification and prognosis in sepsis-related acute kidney injury

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Retrospective study compares SII, NLR, and SIRI for outcome prediction in SA-AKI, indicating SII's superior value.

The aim is to assess which of the SII, NLR, and SIRI best predicts adverse outcomes in patients with sepsis-associated acute kidney injury.
Retrospective analysis of 265 SA-AKI patients admitted to the ICU from June 2022 to June 2025.
SII, NLR, and SIRI were calculated based on admission bloodwork and patients stratified by AKI severity.
Associations with 28-day mortality were evaluated using Spearman correlation, logistic regression, and ROC curve analysis.
SII showed the highest AUC of 0.943 for predicting 28-day mortality, with 89.51% sensitivity and 84.47% specificity.
Logistic regression confirmed SII, NLR, and SIRI as independent risk factors for mortality.
Combined testing of these indices demonstrated better predictive performance than any single indicator.

Jiang et al. (2026) studied this question.

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