What question did this study set out to answer?

This study aims to explore the longitudinal links between childhood neighborhood air pollution exposure and white matter integrity as well as cognition and substance use during adolescence.

August 13, 2026Development and PsychopathologyOpen Access

Longitudinal impacts of childhood neighborhood air pollution exposure on white matter integrity and cognition during childhood to early adolescence

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Authors

JHJulia C. HarrisUniversity of Wisconsin–Milwaukee AKAmy KalkbrennerUniversity of Wisconsin–Milwaukee IWIsabelle WilsonUniversity of Wisconsin–Milwaukee

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Implication

Longitudinal trial examines air pollution impacts on white matter integrity and cognition in adolescents, suggesting age-related variation.

Key Points

This study aims to explore the longitudinal links between childhood neighborhood air pollution exposure and white matter integrity as well as cognition and substance use during adolescence.
Analyzed data from the Adolescent Brain Cognitive Development (ABCD) Study with a sample size of 4,511, mean age 9.9 years.
Utilized linear mixed effects/logistical regression to assess interactions between PM 2.5 exposure and age/sex, controlling for neighborhood factors.
Specifically examined associations of PM 2.5 with fronto-limbic white matter integrity and cognitive outcomes across different ages.
At age 9, greater PM 2.5 exposure correlated with increased fractional anisotropy in key white matter tracts such as the anterior thalamic radiation.
By age 14, PM 2.5 exposure was linked to reduced fractional anisotropy in all assessed tracts and increased mean diffusivity in the superior longitudinal fasciculus.
No significant associations were found between PM 2.5 exposure and cognitive performance or substance use.

Cite This Study

Harris et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76e62b0e0cff3f640a24 https://doi.org/10.1017/s095457942610159x

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Implication

Longitudinal trial examines air pollution impacts on white matter integrity and cognition in adolescents, suggesting age-related variation.

Longitudinal impacts of childhood neighborhood air pollution exposure on white matter integrity and cognition during childhood to early adolescence

Discussion

Member takes

Implication

Key Points

Cite This Study

Longitudinal impacts of childhood neighborhood air pollution exposure on white matter integrity and cognition during childhood to early adolescence

Discussion

Member takes

Implication

Key Points

Cite This Study

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